Approaches to reduce the estimated sample size in clinical trials – A checklist
The following approaches can be considered to reduce the estimated sample size in clinical trials: Objective Choose another objective, e.g. Reduce objectives of study, e.g. phase 2 instead of phase 3, fewer primary/key secondary endpoints, descriptive instead of inferential Change target concept, e.g. physical instead of psychological QOL Operating characteristics: Relax type 1 error Relax…