AstraZeneca-Sanger Drug Combination Prediction DREAM Challenge

Any volunteers? Who wants to join me?

“To accelerate the understanding of drug synergy, AstraZeneca has partnered with the European Bioinformatic Institute, the Sanger Institute, Sage Bionetworks, and the distributed DREAM community to launch the AstraZeneca-Sanger Drug Combination Prediction DREAM Challenge. This Challenge is designed to explore fundamental traits that underlie effective combination treatments and synergistic drug behavior using baseline genomic data, i.e. data collected pretreatment. As the basis of the Challenge, AstraZeneca is releasing ~12k experimentally tested drug combinations measuring cell viability over 119 drugs and 79 cancer cell lines (primarily colon, lung, and breast), and monotherapy drug response data for each drug and cell line. Moreover, in coordination with the Genomics of Drug Sensitivity in Cancer and COSMIC teams at the Sanger Institute, genomic data including gene expression, somatic mutation, copy-number alterations, and methylation data will be released into the public domain and made accessible for Challenge participants through the Challenge data repository.  ”